Anavar is the trade name for an oral anabolic steroid with the chemical name Oxandrolone. The appearance of the drug occurred during active research on anabolic steroids, which lasted from the 1950s to the 1980s. The aim of the research was to develop an anabolic compound that can be considered ideal. Perhaps the developers of Anavar managed to get as close to this goal as possible. The drug has an excellent safety profile and the ratio of the risk of side effects to the expected benefit. It is one of the few steroids that can be prescribed to treat children and women. In these two groups of patients, anabolic steroids are used extremely rarely due to the risk of side effects.
The drug Oxandrolone was first known in 1962. A little later it was introduced by Searle Laboratories (Pfizer Inc) under the Anavar brand. Subsequently, different pharmaceutical companies released Oxandrolone under different trade names. Among them: Protivar, Anatrophil, Antitriol, Lipidex and Lonavar. The drug has become one of the most significant achievements of the pharmaceutical industry, which is confirmed by numerous data on the good tolerability of Anavar by the majority of patients.
Anavar is a dihydrotestosterone derivative whose structure has been modified to give the compound new properties. The first of these changes is C17 alpha alkylation, which allows the drug to be administered orally. The second is the replacement of the carbon in position 2 with oxygen, which enhances the anabolic properties of the compound. Anavar’s anabolic potency is 3-6 times greater than testosterone.
Anavar belongs to the family of dihydrotestosterone
Anavar belongs to the family of dihydrotestosterone (DHT) derivatives. It is actually dihydrotestosterone with methylation at the 17 position. This structural change allows the compound to cross the liver barrier after oral administration, making it more resistant to hepatic metabolism. Another change was made to the structure of the drug: in the first cycloalkane ring of the molecule, the second carbon atom was removed and replaced with oxygen. Thanks to this structural change, Anavar occupies a special position among steroids, because it is the only compound in this group that has a direct modification of the ring structure: the carbon has been completely replaced by an atom of another element. It is likely that this property leads to increased anabolic activity of the hormone compared to the parent substance. One of the mechanisms responsible for the high anabolic efficacy of this modification of Anavar (compared to DHT) is believed to be increased resistance to the enzyme 3-hydroxysteroid dehydrogenase. This enzyme in muscle catalyzes the conversion of DHT to a non-anabolic metabolite. This explains the lack of anabolic effect of dihydrotestosterone on muscle tissue. The compound is inactivated by 3-hydroxysteroid dehydrogenase before acting on androgen receptors in muscle.
What these drugs have in common?
Anavar belongs to the dihydrotestosterone family along with other agents like Masteron, Primobolan, Winstrol, and a few others. What these drugs have in common is that they are all derived from DHT. Therefore, DHT is considered the “parent” hormone for all compounds in the family. Anavar has a distinct advantage of anabolic over androgenic effects (this is clearly evident when comparing the anabolic index (322-630) with the androgenic index (24). As for testosterone, it has a ratio of 100: 100. Of course, Oxandrolone has a much weaker androgenic and significantly lower androgenic effect. stronger anabolic activity than testosterone Anavar’s anabolic activity may be 3 to 6 times greater than that of testosterone, while Anavar’s concurrent androgenic activity is negligible. Moreover, oxandrolone had no estrogenic or progestinic activity.
Of course, the described properties of Anavar make it very attractive for use in sports and bodybuilding. With it, better results can be achieved in the stages of mass building and strength gain when water retention is not desired. This steroid is also used in cases where it is necessary to reduce body fat, maintain muscle mass as much as possible despite caloric restriction. At this point, the build-up of fluids and fats should be avoided again. As seen above, Anavar can be considered a universal drug. In a comparative anabolic steroid review, it is usually called a “mild” agent, although in fact it has quite an impressive anabolic effect. This is confirmed by the corresponding index value from 322 to 630, which is significantly higher than the indexes of testosterone (100) and other commonly used anabolic Primobolan (88). Therefore, when referring to Anavar, the term “mild” may not refer to its anabolic effects as many might believe. The reason for this is the oral dosage form of Anavar as much of the anabolic steroid, when taken internally, can undergo hepatic metabolism. In this respect, the structure of the oral steroids is altered by methylation at the 17-position, which allows the liver to resist damage. Such a modification significantly increases the proportion of the drug that enters the bloodstream, although it does not completely cancel metabolic processes. Some of the drug is still lost, so a range of values is given rather than the exact value of some steroids (mainly oral agents, the anabolic effects of which vary with hepatic metabolism).